Relevance of matrix metalloproteases in non-small cell lung cancer diagnosis.

ABSTRACT:

Background

The need for novel biomarkers that could aid in non-small cell lung cancer (NSCLC) detection, together with the relevance of Matrix Metalloproteases (MMPs) -1, -2, -7, -9 and -10 in lung tumorigenesis, prompted us to assess the diagnostic usefulness of these MMPs and the Tissue Inhibitor of Metalloproteinase (TIMP) -1 in NSCLC patients.

Methods

Markers were evaluated in an initial study cohort (19 NSCLC cases and 19 healthy controls). Those that better performed were analyzed in a larger sample including patients with benign lung diseases. Serum MMPs and TIMP-1 were determined by multiplexed immunoassays. Logistic regression was employed for multivariate analysis of biomarker combinations.

Results

MMPs and TIMP-1 were elevated in the serum of NSCLC patients

SUBMITTER: Blanco-Prieto S 

PROVIDER: S-EPMC5718060 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature