Downstream mediators of Ten-m3 signalling in the developing visual pathway.

ABSTRACT:

Background

The formation of visuotopically-aligned projections in the brain is required for the generation of functional binocular circuits. The mechanisms which underlie this process are unknown. Ten-m3 is expressed in a broad high-ventral to low-dorsal gradient across the retina and in topographically-corresponding gradients in primary visual centres. Deletion of Ten-m3 causes profound disruption of binocular visual alignment and function. Surprisingly, one of the most apparent neuroanatomical changes-dramatic mismapping of ipsilateral, but not contralateral, retinal axons along the representation of the nasotemporal retinal axis-does not correlate well with Ten-m3's expression pattern, raising questions regarding mechanism. The aim of this study was to further our understanding

SUBMITTER: Glendining KA 

PROVIDER: S-EPMC5718065 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature