Investigation of left and right lateral fluid percussion injury in C57BL6/J mice: In vivo functional consequences.

ABSTRACT: Although rodent models of traumatic brain injury (TBI) reliably produce cognitive and motor disturbances, behavioral characterization resulting from left and right hemisphere injuries remains unexplored. Here we examined the functional consequences of targeting the left versus right parietal cortex in lateral fluid percussion injury, on Morris water maze (MWM) spatial memory tasks (fixed platform and reversal) and neurological motor deficits (neurological severity score and rotarod). In the MWM fixed platform task, right lateral injury produced a small delay in acquisition rate compared to left. However, injury to either hemisphere resulted in probe trial deficits. In the MWM reversal task, left-right performance deficits were not evident, though left lateral injury produced mild acquisiti

SUBMITTER: Schurman LD 

PROVIDER: S-EPMC5718151 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature