From child maltreatment to emerging adult problem drinking: Identification of a multilevel internalizing pathway among African American youth.

ABSTRACT: The present study tested the role of FKBP5 binding protein 5 (FKBP5) genetic variation in an internalizing pathway from child maltreatment to emerging adult problem drinking among a sample of African American youth (N = 280) followed prospectively from ages 11 to 20. Specifically, whether childhood internalizing symptoms and emerging adult tension reduction alcohol expectancies sequentially mediate the effect of child maltreatment on emerging adult problem drinking and whether FKBP5 moderates these associations were investigated. The results indicate that individuals with at least one copy of the FKBP5 CATT haplotype (minor alleles) are more vulnerable to traversing the hypothesized internalizing pathway of risk than individuals without this genotypic profile. Taken together our findings h

SUBMITTER: Handley ED 

PROVIDER: S-EPMC5718172 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature