Low Plasma Testosterone Is Associated With Elevated Cardiovascular Disease Biomarkers.

ABSTRACT:

Background

The relation between testosterone (T) plasma concentration and cardiovascular (CV) risk is unclear, with evidence supporting increased risk in men with low and high T levels. Few studies have assessed CV risk as a function of plasma T levels using objective biomarkers.

Aim

To determine the relation between T levels and high-sensitivity CV risk biomarkers.

Methods

Ten thousand forty-one male patients were identified in the database of a commercial clinical laboratory performing biomarker testing. Patients were grouped by total T concentration and associations with the following biomarkers were determined: cardiac troponin I (cTnI), endothelin-1 (ET-1), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-17A, N-terminal pro-B-type natriuretic p

SUBMITTER: Pastuszak AW 

PROVIDER: S-EPMC5718197 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature