Changes in Albuminuria and Subsequent Risk of Incident Kidney Disease.

ABSTRACT:

Background and objectives

Albuminuria is a robust predictor of CKD progression. However, little is known about the associations of changes in albuminuria with the risk of kidney events outside the settings of clinical trials.

Design, setting, participants, & measurements

In a nationwide cohort of 56,946 United States veterans with an eGFR≥60 ml/min per 1.73 m², we examined the associations of 1-year fold changes in albuminuria with subsequent incident CKD (>25% decrease in eGFR reaching <60 ml/min per 1.73 m²) and rapid eGFR decline (eGFR slope <-5 ml/min per 1.73 m² per year) assessed using Cox models and logistic regression, respectively, with adjustment for confounders.

Results

The mean age was 64 (SD, 10) years old; 97% were men, a

SUBMITTER: Sumida K 

PROVIDER: S-EPMC5718265 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature