Stroke-induced immunodepression and dysphagia independently predict stroke-associated pneumonia - The PREDICT study.

ABSTRACT: Stroke-associated pneumonia is a frequent complication after stroke associated with poor outcome. Dysphagia is a known risk factor for stroke-associated pneumonia but accumulating evidence suggests that stroke induces an immunodepressive state increasing susceptibility for stroke-associated pneumonia. We aimed to confirm that stroke-induced immunodepression syndrome is associated with stroke-associated pneumonia independently from dysphagia by investigating the predictive properties of monocytic HLA-DR expression as a marker of immunodepression as well as biomarkers for inflammation (interleukin-6) and infection (lipopolysaccharide-binding protein). This was a prospective, multicenter study with 11 study sites in Germany and Spain, including 486 patients with acute ischemic stroke. Daily s

SUBMITTER: Hoffmann S 

PROVIDER: S-EPMC5718319 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature