Cerebral vascular structure in the motor cortex of adult mice is stable and is not altered by voluntary exercise.

ABSTRACT: The cerebral vasculature provides blood flow throughout the brain, and local changes in blood flow are regulated to match the metabolic demands of the active brain regions. This neurovascular coupling is mediated by real-time changes in vessel diameter and depends on the underlying vascular network structure. Neurovascular structure is configured during development by genetic and activity-dependent factors. In adulthood, it can be altered by experiences such as prolonged hypoxia, sensory deprivation and seizure. Here, we have sought to determine whether exercise could alter cerebral vascular structure in the adult mouse. We performed repeated in vivo two-photon imaging in the motor cortex of adult transgenic mice expressing membrane-anchored green fluorescent protein in endothelial cells (

SUBMITTER: Cudmore RH 

PROVIDER: S-EPMC5718320 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature