Region-specific permeability of the blood-brain barrier upon pericyte loss.

ABSTRACT: The blood-brain barrier (BBB) regulates differing needs of the various brain regions by controlling transport of blood-borne components from the neurovascular circulation into the brain parenchyma. The mechanisms underlying region-specific transport across the BBB are not completely understood. Previous work showed that pericytes are key regulators of BBB function. Here we investigated whether pericytes influence BBB permeability in a region-specific manner by analysing the regional permeability of the BBB in the pdgf-b ^ret/ret mouse model of pericyte depletion. We show that BBB permeability is heterogeneous in pdgf-b ^ret/ret mice, being significantly higher in the cortex, striatum and hippocampus compared to the interbrain and midbrain. However, we show that this reg

SUBMITTER: Villasenor R 

PROVIDER: S-EPMC5718326 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature