Multimodal partial volume correction: Application to [¹¹C]PIB PET/MRI myelin imaging in multiple sclerosis.

ABSTRACT: The [¹¹C]PIB PET tracer, originally developed for amyloid imaging, has been recently repurposed to quantify demyelination and remyelination in multiple sclerosis (MS). Myelin PET imaging, however, is limited by its low resolution that deteriorates the quantification accuracy of white matter (WM) lesions. Here, we introduce a novel partial volume correction (PVC) method called Multiresolution-Multimodal Resolution-Recovery (MM-RR), which uses the wavelet transform and a synergistic statistical model to exploit MRI structural images to improve the resolution of [¹¹C]PIB PET myelin imaging. MM-RR performance was tested on a phantom acquisition and in a dataset comprising [¹¹C]PIB PET and MR T1- and T2-weighted images of 8 healthy controls and 20 MS patients. F

SUBMITTER: Grecchi E 

PROVIDER: S-EPMC5718330 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature