Mig-6 deficiency cooperates with oncogenic Kras to promote mouse lung tumorigenesis.

ABSTRACT:

Objectives

Lung cancer is the leading cause of cancer related deaths worldwide and mutation activating KRAS is one of the most frequent mutations found in lung adenocarcinoma. Identifying regulators of KRAS may aid in the development of therapies to treat this disease. The mitogen-induced gene 6, MIG-6, is a small adaptor protein modulating signaling in cells to regulate the growth and differentiation in multiple tissues. Here, we investigated the role of Mig-6 in regulating adenocarcinoma progression in the lungs of genetically engineered mice with activation of Kras.

Materials and methods

Using the CCSP^Cre mouse to specifically activate expression of the oncogenic Kras^G12D in Club cells, we investigated the expression of Mig-6 in CCSP^CreKra

SUBMITTER: Liu J 

PROVIDER: S-EPMC5718380 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature