Urinary metabolomic analysis to identify preterm neonates exposed to histological chorioamnionitis: A pilot study.

ABSTRACT:

Objective

Chorioamnionitis is a leading cause of preterm birth worldwide, with higher incidence at lower gestational ages. An early and reliable diagnosis of histological chorioamnionitis (HCA) in preterm infants may be helpful in guiding postnatal management, especially the administration of prophylactic antibiotics to prevent early-onset sepsis. The main aim of this study was to investigate metabolomic analysis of urines collected in the first 24 hours of life as diagnostic tool of HCA.

Methods

Gestational age-, birth weight-, delivery mode- and sex- matched (1:2) preterm neonates (< 35 weeks' gestation) born to mothers with or without HCA were enrolled from an observational study. Gas chromatography-mass spectrometry (GC-MS)-based metabolomic analysis was performed on uri

SUBMITTER: Fattuoni C 

PROVIDER: S-EPMC5718427 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature