The Relationship Between Regional Anesthesia and Cancer: A Metaanalysis.

ABSTRACT:

Background

Some studies have suggested using epidural analgesia after cancer surgery to reduce metastasis. This article examines the relationship between regional anesthesia (RA) and cancer metastasis in an array of cancers.

Methods

We conducted a review of the literature using PubMed and included 67,577 patients across 28 studies in a metaanalysis, evaluating the hazard ratios (HRs) of overall survival, recurrence-free survival, and biochemical recurrence-free survival.

Results

We found no benefit to RA as it relates to cancer. The HR was 0.92 for overall survival, 1.06 for recurrence-free survival, and 1.05 for biochemical recurrence-free survival. Despite the overall analysis showing no benefit, we found some benefit when we evaluated only the randomized trials. Ho

SUBMITTER: Grandhi RK 

PROVIDER: S-EPMC5718448 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature