The effect of somatostatin analogues on postoperative outcomes following pancreatic surgery: A meta-analysis.

ABSTRACT:

Background

Leakage from the pancreatic stump is a leading cause of morbidity following pancreatic surgery. It is essential to evaluate the effect of somatostatin analogues (SAs) following pancreatic surgery by analyzing all recent clinical trials.

Data sources

We performed a literature search in the Medline, EMBASE, Cochrane Central Register of Controlled Trials and Web of Science databases up to May 29, 2016. Publication bias was assessed with Egger's test. Study quality was assessed using the Jadad Composite Scale.

Conclusions

Twelve clinical trials involving 1703 patients from Jan 1st, 2000 to May 29th, 2016 were included in the study. With improvements in surgical management and peri-operative patient care, prophylactic use of somatostatin and its analogues reduce

SUBMITTER: Han X 

PROVIDER: S-EPMC5718483 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature