Distinct fecal and oral microbiota composition in human type 1 diabetes, an observational study.

ABSTRACT:

Objective

Environmental factors driving the development of type 1 diabetes (T1D) are still largely unknown. Both animal and human studies have shown an association between altered fecal microbiota composition, impaired production of short-chain fatty acids (SCFA) and T1D onset. However, observational evidence on SCFA and fecal and oral microbiota in adults with longstanding T1D vs healthy controls (HC) is lacking.

Research design and methods

We included 53 T1D patients without complications or medication and 50 HC matched for age, sex and BMI. Oral and fecal microbiota, fecal and plasma SCFA levels, markers of intestinal inflammation (fecal IgA and calprotectin) and markers of low-grade systemic inflammation were measured.

Results

Oral microbiota were markedly differe

SUBMITTER: de Groot PF 

PROVIDER: S-EPMC5718513 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature