Association of Antibiotics, Airway Microbiome, and Inflammation in Infants with Cystic Fibrosis.

ABSTRACT:

Rationale

The underlying defect in the cystic fibrosis (CF) airway leads to defective mucociliary clearance and impaired bacterial killing, resulting in endobronchial infection and inflammation that contributes to progressive lung disease. Little is known about the respiratory microbiota in the early CF airway and its relationship to inflammation.

Objectives

To examine the bacterial microbiota and inflammatory profiles in bronchoalveolar lavage fluid and oropharyngeal secretions in infants with CF.

Methods

Infants with CF from U.S. and Australian centers were enrolled in a prospective, observational study examining the bacterial microbiota and inflammatory profiles of the respiratory tract. Bacterial diversity and density (load) were measured. Lavage samples were anal

SUBMITTER: Pittman JE 

PROVIDER: S-EPMC5718571 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature