Generative mathematical modelling to demonstrate virtual simulations of neovascular age related macular degeneration.

ABSTRACT:

Purpose

To develop a generative mathematical model of wet age-related macular degeneration (AMD) and model the impact of injections of anti-vascular endothelial growth factor to virtual patients with the condition.

Methods

We isolated key pathophysiological components of macular degeneration in terms of macular edema development and response to anti-vascular endothelial growth factor (VEGF) agents. We developed mathematical models for each of these components using constants determined from published biological experimentation. Consequently, we combined the mathematical models of the separate components to arrive at an end-to-end model of the evolution of macular edema size and its response to treatment.

Results

We present a series of simulations based upon our ideali

SUBMITTER: Hoyle D 

PROVIDER: S-EPMC5718607 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature