Arsenic exposure and intestinal microbiota in children from Sirajdikhan, Bangladesh.

ABSTRACT:

Background

Arsenic has antimicrobial properties at high doses yet few studies have examined its effect on gut microbiota. This warrants investigation since arsenic exposure increases the risk of many diseases in which gut microbiota have been shown to play a role. We examined the association between arsenic exposure from drinking water and the composition of intestinal microbiota in children exposed to low and high arsenic levels during prenatal development and early life.

Results

16S rRNA gene sequencing revealed that children with high arsenic exposure had a higher abundance of Proteobacteria in their stool compared to matched controls with low arsenic exposure. Furthermore, whole metagenome shotgun sequencing identified 332 bacterial SEED functions that were enriched in t

SUBMITTER: Dong X 

PROVIDER: S-EPMC5718612 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature