Plasma Amino Acids Stimulate Uncoupled Respiration of Muscle Subsarcolemmal Mitochondria in Lean but Not Obese Humans.

ABSTRACT:

Context

Obesity is associated with mitochondrial dysfunction in skeletal muscle. Increasing the plasma amino acid (AA) concentrations stimulates mitochondrial adenosine triphosphate (ATP) production in lean individuals.

Objective

To determine whether acute elevation in plasma AAs enhances muscle mitochondrial respiration and ATP production in subsarcolemmal (SS) and intermyofibrillar (IMF) mitochondria in obese adults.

Design

Assessment of SS and IMF mitochondrial function during saline (i.e., control) and AA infusions.

Participants

Eligible participants were healthy lean (body mass index, <25 kg/m2; age, 37 ± 3 years; n = 10) and obese (body mass index >30 kg/m2; age 35 ± 3 years; n = 11) subjects.

Intervention

Single trial of saline infusion followed b

SUBMITTER: Kras KA 

PROVIDER: S-EPMC5718694 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature