The Role of Age and Excess Body Mass Index in Progression to Type 1 Diabetes in At-Risk Adults.

ABSTRACT:

Background

Given the global rise in both type 1 diabetes incidence and obesity, the role of body mass index (BMI) on type 1 diabetes pathophysiology has gained great interest. Sustained excess BMI in pediatric participants of the TrialNet Pathway to Prevention (PTP) cohort increased risk for progression to type 1 diabetes, but the effects of age and obesity in adults remain largely unknown.

Objective

To determine the effect of age and sustained obesity on the risk for type 1 diabetes in adult participants in the TrialNet PTP cohort (i.e., nondiabetic autoantibody-positive relatives of patients with type 1 diabetes).

Research design and methods

Longitudinally accumulated BMI >25 kg/m2 was calculated to generate a cumulative excess BMI (ceBMI) for each participant, with

SUBMITTER: Ferrara CT 

PROVIDER: S-EPMC5718698 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature