Thermoneutrality but Not UCP1 Deficiency Suppresses Monocyte Mobilization Into Blood.

ABSTRACT:

Rationale

Ambient temperature is a risk factor for cardiovascular disease. Cold weather increases cardiovascular events, but paradoxically, cold exposure is metabolically protective because of UCP1 (uncoupling protein 1)-dependent thermogenesis.

Objective

We sought to determine the differential effects of ambient environmental temperature challenge and UCP1 activation in relation to cardiovascular disease progression.

Methods and results

Using mouse models of atherosclerosis housed at 3 different ambient temperatures, we observed that cold temperature enhanced, whereas thermoneutral housing temperature inhibited atherosclerotic plaque growth, as did deficiency in UCP1. However, whereas UCP1 deficiency promoted poor glucose tolerance, thermoneutral housing enhanced glu

SUBMITTER: Williams JW 

PROVIDER: S-EPMC5718914 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature