Extending the Case-Control Design to Longitudinal Data: Stratified Sampling Based on Repeated Binary Outcomes.

ABSTRACT: We detail study design options that generalize case-control sampling when longitudinal outcome data are already collected as part of a primary cohort study, but new exposure data must be retrospectively processed for a secondary analysis. Furthermore, we assume that cost will limit the size of the subsample that can be evaluated. We describe a novel class of stratified outcome-dependent sampling designs for longitudinal binary response data where distinct strata are created for subjects who never, sometimes, and always experienced the event of interest during longitudinal follow-up. Individual designs within this class are differentiated by the stratum-specific sampling probabilities. We show for parameters associated with time-varying exposures, subjects who experience the event/outcome a

SUBMITTER: Schildcrout JS 

PROVIDER: S-EPMC5718932 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature