Aspirin Use and Mortality in Two Contemporary US Cohorts.

ABSTRACT:

Background

Daily aspirin use has been recommended for secondary prevention of cardiovascular disease, but its use for primary prevention remains controversial.

Methods

We followed 440,277 men and women from the NIH-AARP Diet and Health Study (ages 50-71) and the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (ages 55-74) for mortality for 13 years on average. Frequency of aspirin use was ascertained through self-report, and cause of death by death certificates. We calculated multivariate hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality using Cox proportional hazards models for each cohort and combined by meta-analysis.

Results

We found a consistent U-shaped relationship between aspirin use and mortality in both studies, with differe

SUBMITTER: Huang WY 

PROVIDER: S-EPMC5718934 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature