Three-dimensional mapping of brain venous oxygenation using R2* oximetry.

ABSTRACT:

Purpose

Cerebral venous oxygenation (Y_v ) is an important biomarker for brain diseases. This study aims to develop an R2*-based MR oximetry that can measure cerebral Y_v in 3D.

Methods

This technique separates blood signal from tissue by velocity-encoding phase contrast and measures the R2* of pure blood by multi-gradient-echo acquisition. The blood R2* was converted to Y_v using an R2*-versus-oxygenation (Y) calibration curve, which was obtained by in vitro bovine blood experiments. Reproducibility, sensitivity, validity, and resolution dependence of the technique were evaluated.

Results

In vitro R2*-Y calibration plot revealed a strong dependence of blood R2* on oxygenation, with additional dependence on hematocrit. In vivo results dem

SUBMITTER: Mao D 

PROVIDER: S-EPMC5718988 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature