Human CD26^high T cells elicit tumor immunity against multiple malignancies via enhanced migration and persistence.

ABSTRACT: CD8⁺ T lymphocytes mediate potent immune responses against tumor, but the role of human CD4⁺ T cell subsets in cancer immunotherapy remains ill-defined. Herein, we exhibit that CD26 identifies three T helper subsets with distinct immunological properties in both healthy individuals and cancer patients. Although CD26^neg T cells possess a regulatory phenotype, CD26^int T cells are mainly naive and CD26^high T cells appear terminally differentiated and exhausted. Paradoxically, CD26^high T cells persist in and regress multiple solid tumors following adoptive cell transfer. Further analysis revealed that CD26^high cells have a rich chemokine receptor profile (including CCR2 and CCR5), profound cytotoxicity (Granzyme B and

SUBMITTER: Bailey SR 

PROVIDER: S-EPMC5719008 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature