Ontology highlight
ABSTRACT:
SUBMITTER: Almeida F
PROVIDER: S-EPMC5719036 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Almeida Fausto F Wolf Julie M JM da Silva Thiago Aparecido TA DeLeon-Rodriguez Carlos M CM Rezende Caroline Patini CP Pessoni André Moreira AM Fernandes Fabrício Freitas FF Silva-Rocha Rafael R Martinez Roberto R Rodrigues Marcio L ML Roque-Barreira Maria Cristina MC Casadevall Arturo A
Nature communications 20171206 1
Cryptococcus neoformans is an encapsulated fungal pathogen that causes cryptococcosis, which is a major opportunistic infection in immunosuppressed individuals. Mammalian β-galactoside-binding protein Galectin-3 (Gal-3) modulates the host innate and adaptive immunity, and plays significant roles during microbial infections including some fungal diseases. Here we show that this protein plays a role also in C. neoformans infection. We find augmented Gal-3 serum levels in human and experimental inf ...[more]