Ontology highlight
ABSTRACT:
SUBMITTER: Scholler P
PROVIDER: S-EPMC5719040 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Nature communications 20171206 1
Antibodies have enormous therapeutic and biotechnology potential. G protein-coupled receptors (GPCRs), the main targets in drug development, are of major interest in antibody development programs. Metabotropic glutamate receptors are dimeric GPCRs that can control synaptic activity in a multitude of ways. Here we identify llama nanobodies that specifically recognize mGlu2 receptors, among the eight subtypes of mGluR subunits. Among these nanobodies, DN10 and 13 are positive allosteric modulators ...[more]