Ontology highlight
ABSTRACT:
SUBMITTER: Dias-Teixeira KL
PROVIDER: S-EPMC5719050 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Scientific reports 20171206 1
Leishmania parasites utilize adaptive evasion mechanisms in infected macrophages to overcome host defenses and proliferate. We report here that the PERK/eIF2α/ATF4 signaling branch of the integrated endoplasmic reticulum stress response (IERSR) is activated by Leishmania and this pathway is important for Leishmania amazonensis infection. Knocking down PERK or ATF4 expression or inhibiting PERK kinase activity diminished L. amazonensis infection. Knocking down ATF4 decreased NRF2 expression and i ...[more]