Cardiovascular mortality and oral antidiabetic drugs: protocol for a systematic review and network meta-analysis.

ABSTRACT:

Introduction

Cardiovascular diseases are the leading cause of morbidity and mortality among individuals with diabetes. Despite the beneficial effects of antidiabetic drugs (ADDs) in terms of lowering haemoglobin A1c, several ADDs have been shown to increase the risk of cardiovascular events. Given the high prevalence of cardiovascular disease among individuals with diabetes, it is important to weigh the benefits of ADDs against their cardiovascular safety. Therefore, the objective of the current study is to conduct a systematic review with network meta-analysis to compare the effects of different oral pharmacological classes of ADDs on cardiovascular safety.

Methods and analysis

Randomised clinical trials (RCTs) and observational studies published in English up to 31 January

SUBMITTER: Goyat R 

PROVIDER: S-EPMC5719279 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature