Identification of sRNA mediated responses to nutrient depletion in Burkholderia pseudomallei.

ABSTRACT: The Burkholderia genus includes many species that are known to survive in diverse environmental conditions including low nutrient environments. One species, Burkholderia pseudomallei is a versatile pathogen that can survive in a wide range of hosts and environmental conditions. In this study, we investigated how a nutrient depleted growth environment evokes sRNA mediated responses by B. pseudomallei. Computationally predicted B. pseudomallei D286 sRNAs were mapped to RNA-sequencing data for cultures grown under two conditions: (1) BHIB as a nutrient rich media reference environment and (2) M9 media as a nutrient depleted stress environment. The sRNAs were further selected to identify potentially cis-encoded systems by investigating their possible interactions with their flanking genes. The

SUBMITTER: Mohd-Padil H 

PROVIDER: S-EPMC5719362 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature