Structural and functional annotation of hypothetical proteins of human adenovirus: prioritizing the novel drug targets.

ABSTRACT:

Objective

Human adenoviruses are small double stranded DNA viruses that provoke vast array of human diseases. Next generation sequencing techniques increase genomic data of HAdV rapidly, which increase their serotypes. The complete genome sequence of human adenovirus shows that it contains large amount of proteins with unknown cellular or biochemical function, known as hypothetical proteins. Hence, it is indispensable to functionally and structurally annotate these proteins to get better understanding of the novel drug targets. The purpose was the characterization of 38 randomly retrieved hypothetical proteins through determination of their physiochemical properties, subcellular localization, function, structure and ligand binding sites using various sequence and structure based bi

SUBMITTER: Naveed M 

PROVIDER: S-EPMC5719520 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature