Immunoproteomics of Plasmodium falciparum-infected red blood cell membrane fractions.

ABSTRACT:

Background

The surface of infected red blood cells (iRBCs) has been widely investigated because of the molecular complexity and pathogenesis mechanisms involved. Asymptomatic individuals are important in the field because they can perpetuate transmission as natural reservoirs and present a challenge for diagnosing malaria because of their low levels of circulating parasites. Recent studies of iRBC antibody recognition have shown that responses are quantitatively similar in symptomatic and asymptomatic infections, but no studies have characterised the plasmodial proteins targeted by this response.

Objectives

Our main objective was to identify Plasmodium falciparum proteins associated with iRBC ghosts recognised by antibodies in the sera of symptomatic and asymptomatic individ

SUBMITTER: Cabral FJ 

PROVIDER: S-EPMC5719555 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature