Protein kinase C α enhances migration of breast cancer cells through FOXC2-mediated repression of p120-catenin.

ABSTRACT:

Background

Despite recent advances in the diagnosis and treatment of breast cancer, metastasis remains the main cause of death. Since migration of tumor cells is considered a prerequisite for tumor cell invasion and metastasis, a pressing goal in tumor biology has been to elucidate factors regulating their migratory activity. Protein kinase C alpha (PKCα) is a serine-threonine protein kinase implicated in cancer metastasis and associated with poor prognosis in breast cancer patients. In this study, we set out to define the signaling axis mediated by PKCα to promote breast cancer cell migration.

Methods

Oncomine™ overexpression analysis was used to probe for PRKCA (PKCα) and FOXC2 expression in mRNA datasets. The heat map of PRKCA, FOXC2, and CTNND1 were obtained from the UC

SUBMITTER: Pham TND 

PROVIDER: S-EPMC5719564 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature