Helicobacter-induced gastric inflammation alters the properties of gastric tissue stem/progenitor cells.

ABSTRACT:

Background

Although Helicobacter-induced gastric inflammation is the major predisposing factor for gastric carcinogenesis, the precise mechanism by which chronic gastritis causes gastric cancer remains unclear. Intestinal and spasmolytic polypeptide-expressing metaplasia (SPEM) is considered as precancerous lesions, changes in epithelial tissue stem/progenitor cells after chronic inflammation has not been clarified yet. In this study, we utilized three-dimensional gastric epithelial cell culture systems that could form organoids, mimicking gastric epithelial layer, and characterized the changes in epithelial cells after chronic Helicobacter felis infection.

Methods

We used three mice model; 1) long-term H. felis infection, 2) H. felis eradication, and 3) MNU chemical carcino

SUBMITTER: Shibata W 

PROVIDER: S-EPMC5719643 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature