A study on spike focus dependence of high-frequency activity in idiopathic focal epilepsy in childhood.

ABSTRACT:

Objective

Spike foci in benign epilepsy with centrotemporal spikes (BECTS) are related to seizure semiologies, but this relationship is inconspicuous in Panayiotopoulos syndrome (PS). We analyzed spike-associated high-frequency activity (HFA) and its relationship to spike foci in the electroencephalograms (EEGs) of patients with BECTS and PS in order to elucidate the pathophysiology of these epileptic syndromes.

Methods

In 35 patients with BECTS and 29 with PS, focal spikes in scalp sleep EEGs were first classified by clustering according to their characteristics, including shape and distribution. For each patient, three or fewer spike clusters were investigated by time-frequency spectral analysis and single-dipole analysis using a realistic three-dimensional head model to e

SUBMITTER: Shibata T 

PROVIDER: S-EPMC5719832 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature