Decreased functional connectivity within a language subnetwork in benign epilepsy with centrotemporal spikes.

ABSTRACT:

Objective

Benign epilepsy with centrotemporal spikes (BECTS, also known as Rolandic epilepsy) is a common epilepsy syndrome that is associated with literacy and language impairments. The neural mechanisms of the syndrome are not known. The primary objective of this study was to test the hypothesis that functional connectivity within the language network is decreased in children with BECTS. We also tested the hypothesis that siblings of children with BECTS have similar abnormalities.

Methods

Echo planar magnetic resonance (MR) imaging data were acquired from 25 children with BECTS, 12 siblings, and 20 healthy controls, at rest. After preprocessing with particular attention to intrascan motion, the mean signal was extracted from each of 90 regions of interest. Sparse, undirect

SUBMITTER: McGinnity CJ 

PROVIDER: S-EPMC5719846 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature