Constructing a comprehensive gene co-expression based interactome in Bos taurus.

ABSTRACT: Integrating genomic information into cattle breeding is an important approach to exploring genotype-phenotype relationships for complex traits related to diary and meat production. To assist with genomic-based selection, a reference map of interactome is needed to fully understand and identify the functional relevant genes. To this end, we constructed a co-expression analysis of 92 tissues and this represents the systematic exploration of gene-gene relationship in Bos taurus. By using robust WGCNA (Weighted Gene Correlation Network Analysis), we described the gene co-expression network of 5,000 protein-coding genes with majority variations in expression across 92 tissues. Further module identifications found 55 highly organized functional clusters representing diverse cellular activ

SUBMITTER: Chen Y 

PROVIDER: S-EPMC5719962 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature