Change in FK506 binding protein 5 (FKBP5) methylation over time among preschoolers with adversity.

ABSTRACT: FK506 binding protein 5 (FKBP5) alters stress response system functioning, and childhood maltreatment is associated with methylation of the FKBP5 gene. Yet it is unknown if maltreatment contributes to change in FKBP5 methylation over time. The current study draws upon a sample of 231 preschoolers, including 123 with child welfare documentation of moderate to severe maltreatment in the past 6 months, to understand if maltreatment contributes to change in FKBP5 methylation over a 6-month period. Review of child protection records and semistructured interviews in the home were used to assess maltreatment and exposure to other contextual stressors, as well as service utilization. Methylation of FKBP5 at two CpG sites in intron 7 was measured from saliva DNA at the time of initial study enrollm

SUBMITTER: Parade SH 

PROVIDER: S-EPMC5720139 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature