ADHD, learning difficulties and sleep disturbances associated with KCNJ11-related neonatal diabetes.

ABSTRACT:

Objectives

Mutations in KCNJ11 are the most common cause of permanent neonatal diabetes mellitus (NDM). Approximately 25% of patients have obvious neurological dysfunction, but whether milder related problems might be more common has been unclear. We sought to assess the prevalence of parental concerns about learning, behavior, attention deficit hyperactivity disorder (ADHD), social competency, and sleep in subjects with KCNJ11-related NDM compared to unaffected sibling controls.

Study design

Subjects or their guardians in the University of Chicago Monogenic Diabetes Registry completed a survey examining learning, behavior, ADHD and sleep. Thirty subjects with KCNJ11 -related NDM and 25 unaffected sibling controls were assessed. Data were analyzed using GraphPad Prism 6. Non

SUBMITTER: Landmeier KA 

PROVIDER: S-EPMC5720354 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature