Orbitofrontal cortex activity and connectivity predict future depression symptoms in adolescence.

ABSTRACT:

Background

Major depressive disorder is a leading cause of disability worldwide; however, little is known about pathological mechanisms involved in its development. Research in adolescent depression has focused on reward sensitivity and striatal mechanisms implementing it. The contribution of loss sensitivity to future depression, as well as the orbitofrontal cortex (OFC) mechanisms critical for processing losses and rewards, remain unexplored. Furthermore, it is unclear whether OFC functioning interacts with familial history in predicting future depression.

Methods

In this longitudinal study we recorded functional magnetic resonance imaging (fMRI) data while 229 adolescent females with or without parental history of depression completed a monetary gambling task. We examined

SUBMITTER: Jin J 

PROVIDER: S-EPMC5720380 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature