Urinary Calcium Excretion and Risk of Chronic Kidney Disease in the General Population.

ABSTRACT:

Introduction

High urinary calcium excretion (UCaE) has been shown to lead to accelerated renal function decline in individuals with renal tubular diseases. It is not known whether this association also exists in the general population. Therefore, we investigated whether high UCaE is associated with risk of developing chronic kidney disease (CKD) in community-dwelling subjects.

Methods

Urine samples of 5491 subjects who were free of CKD at baseline and participated in the Prevention of Renal and Vascular End-Stage Disease study (a prospective, observational, general population-based cohort of Dutch men and women aged 28-75 years) were examined for UCaE. UCa concentration was measured in two 24-hour urine samples at baseline (1997-1998) by indirect potentiometry. UCaE was trea

SUBMITTER: Taylor JM 

PROVIDER: S-EPMC5720525 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature