Functional lung MRI for regional monitoring of patients with cystic fibrosis.

ABSTRACT:

Purpose

To test quantitative functional lung MRI techniques in young adults with cystic fibrosis (CF) compared to healthy volunteers and to monitor immediate treatment effects of a single inhalation of hypertonic saline in comparison to clinical routine pulmonary function tests.

Materials and methods

Sixteen clinically stable CF patients and 12 healthy volunteers prospectively underwent two functional lung MRI scans and pulmonary function tests before and 2h after a single treatment of inhaled hypertonic saline or without any treatment. MRI-derived oxygen enhanced T1 relaxation measurements, fractional ventilation, first-pass perfusion parameters and a morpho-functional CF-MRI score were acquired.

Results

Compared to healthy controls functional lung MRI detected and q

SUBMITTER: Kaireit TF 

PROVIDER: S-EPMC5720731 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature