Transcription factors, coregulators, and epigenetic marks are linearly correlated and highly redundant.

ABSTRACT: The DNA microstates that regulate transcription include sequence-specific transcription factors (TFs), coregulatory complexes, nucleosomes, histone modifications, DNA methylation, and parts of the three-dimensional architecture of genomes, which could create an enormous combinatorial complexity across the genome. However, many proteins and epigenetic marks are known to colocalize, suggesting that the information content encoded in these marks can be compressed. It has so far proved difficult to understand this compression in a systematic and quantitative manner. Here, we show that simple linear models can reliably predict the data generated by the ENCODE and Roadmap Epigenomics consortia. Further, we demonstrate that a small number of marks can predict all other marks with high average cor

SUBMITTER: Ahsendorf T 

PROVIDER: S-EPMC5720766 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature