The effect of spatial randomness on the average fixation time of mutants.

ABSTRACT: The mean conditional fixation time of a mutant is an important measure of stochastic population dynamics, widely studied in ecology and evolution. Here, we investigate the effect of spatial randomness on the mean conditional fixation time of mutants in a constant population of cells, N. Specifically, we assume that fitness values of wild type cells and mutants at different locations come from given probability distributions and do not change in time. We study spatial arrangements of cells on regular graphs with different degrees, from the circle to the complete graph, and vary assumptions on the fitness probability distributions. Some examples include: identical probability distributions for wild types and mutants; cases when only one of the cell types has random fitness values while the o

SUBMITTER: Farhang-Sardroodi S 

PROVIDER: S-EPMC5720826 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature