Inflammation-Related Morbidity and Mortality Among HIV-Positive Adults: How Extensive Is It?

ABSTRACT:

Objective

To determine the rate of grade 4, potentially life-threatening events not attributable to AIDS, cardiovascular disease (CVD), or non-AIDS cancer among participants on antiretroviral therapy and to describe associations of these events with interleukin-6 (IL-6) and D-dimer.

Design

Cohort study.

Methods

HIV-infected participants on antiretroviral therapy (N = 3568) with an HIV-RNA level ≤ 500 copies/mL were followed for grade 4, AIDS, CVD, non-AIDS cancer, and all-cause mortality events. Grade 4 events were further classified masked to biomarker levels as reflecting chronic inflammation-related disease (ChrIRD) or not (non-ChrIRD). Associations of baseline IL-6 and D-dimer with events were studied using Cox models.

Results

Over a median follow-up of 4.3

SUBMITTER: Hart BB 

PROVIDER: S-EPMC5720921 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature