Recent Progress in the Development of TSPO PET Ligands for Neuroinflammation Imaging in Neurological Diseases.

ABSTRACT: Neuroinflammation is heavily associated with various neurological diseases including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and stroke. It is strongly characterized by the activation of microglia which can be visualized using position emission tomography (PET). Traditionally, translocator protein 18 kDa (TSPO) has been the preferred target for imaging the inflammatory progression of the microglial component. TSPO is expressed in the outer mitochondrial membrane and present in very low concentrations in the healthy human brain, but is markedly upregulated in response to brain injury and inflammation. Due to its value as a marker of microglial activation and subsequent utility for evaluating neuroinflammation in CNS disorders, several classes of TSPO radioligands have

SUBMITTER: Alam MM 

PROVIDER: S-EPMC5721086 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature