Model predictions of deformation, embolization and permeability of partially obstructive blood clots under variable shear flow.

ABSTRACT: Thromboembolism, one of the leading causes of morbidity and mortality worldwide, is characterized by formation of obstructive intravascular clots (thrombi) and their mechanical breakage (embolization). A novel two-dimensional multi-phase computational model is introduced that describes active interactions between the main components of the clot, including platelets and fibrin, to study the impact of various physiologically relevant blood shear flow conditions on deformation and embolization of a partially obstructive clot with variable permeability. Simulations provide new insights into mechanisms underlying clot stability and embolization that cannot be studied experimentally at this time. In particular, model simulations, calibrated using experimental intravital imaging of an established

SUBMITTER: Xu S 

PROVIDER: S-EPMC5721151 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature