Identifying spatio-temporal dynamics of Ebola in Sierra Leone using virus genomes.

ABSTRACT: Containing the recent West African outbreak of Ebola virus (EBOV) required the deployment of substantial global resources. Despite recent progress in analysing and modelling EBOV epidemiological data, a complete characterization of the spatio-temporal spread of Ebola cases remains a challenge. In this work, we offer a novel perspective on the EBOV epidemic in Sierra Leone that uses individual virus genome sequences to inform population-level, spatial models. Calibrated to phylogenetic linkages of virus genomes, these spatial models provide unique insight into the disease mobility of EBOV in Sierra Leone without the need for human mobility data. Consistent with other investigations, our results show that the spread of EBOV during the beginning and middle portions of the epidemic strongly de

SUBMITTER: Gustafson KB 

PROVIDER: S-EPMC5721162 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature