Neutralization of Naja naja venom induced lethality, edema and myonecrosis by ethanolic root extract of Coix lacryma-jobi.

ABSTRACT: Coix lacryma-jobi, commonly known as job's tear, is a tall grain-bearing tropical plant of the family Poaceae. The ethanolic root extract (ERE) of the plant was investigated for the first time for anti-venom activity against Indian cobra Naja naja venom. In-vitro studies were conducted to determine neutralization of phospholipase A₂ (PLA₂) activity of the Naja naja venom by the ERE. ERE showed significant inhibition of PLA₂ activity, which was further confirmed from effective neutralization of human red blood cells (HRBC) lysis induced by the venom. In addition, venom-induced proteolysis, fibrinogenolysis, DNase activity were also neutralized by the ERE, which contained carbohydrates, glycolides, resins and tannins. Oral a

SUBMITTER: Rajesh KS 

PROVIDER: S-EPMC5721210 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature