A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay.

ABSTRACT:

Background

Large-scale image sets acquired by automated microscopy of perturbed samples enable a detailed comparison of cell states induced by each perturbation, such as a small molecule from a diverse library. Highly multiplexed measurements of cellular morphology can be extracted from each image and subsequently mined for a number of applications.

Findings

This microscopy dataset includes 919 265 five-channel fields of view, representing 30 616 tested compounds, available at "The Cell Image Library" (CIL) repository. It also includes data files containing morphological features derived from each cell in each image, both at the single-cell level and population-averaged (i.e., per-well) level; the image analysis workflows that generated the morphological features are also pr

SUBMITTER: Bray MA 

PROVIDER: S-EPMC5721342 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature